MR elastography of hydrocephalus

Adam J. Pattison; S. Scott Lollis; Phillip R. Perríñez; John B. Weaver; Keith D. Paulsen

doi:10.1117/12.811820

27 February 2009 MR elastography of hydrocephalus

Adam J. Pattison, S. Scott Lollis, Phillip R. Perríñez, John B. Weaver, Keith D. Paulsen

Proceedings Volume 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging; 72620A (2009) https://doi.org/10.1117/12.811820
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Hydrocephalus occurs due to a blockage in the transmission of cerebrospinal fluid (CSF) in either the ventricles or subarachnoid space. Characteristics of this condition include increased intracranial pressure, which can result in neurologic deterioration ^[1]. Magnetic resonance elastography (MRE) is an imaging technique that estimates the mechanical properties of tissue in vivo. While some investigations of brain tissue have been performed using MRE ^[2,3,4,5], the effects due to changes in interstitial pressure and fluid content on the mechanical properties of the brain remain unknown. The purpose of this work is to assess the potential of MRE to differentiate between the reconstructed properties of normal and hydrocephalic brains. MRE data was acquired in 18 female feline subjects, 12 of which received kaolin injections resulting in an acute form of hydrocephalus. In each animal, four MRE scans were performed during the process including one pre-injection and three post-injection scans. The elastic parameters were obtained using a subzone-based reconstruction algorithm that solves Navier's equations for linearly elastic materials ^[6]. The remaining cats were used as controls, injected with saline instead of kaolin. To determine the state of hydrocephalus, ventricular volume was estimated from segmenting anatomical images. The mean ventricular volume of hydrocephalic cats significantly increased (P ⪅ 0.0001) between the first and second scans. The mean volume was not observed to increase (P ⪆ 0.5) for the control cats. Also, there was an observable increase in the recorded elastic shear modulus of brain tissue in the normal and hydrocephalic acquisitions. Results suggest that MRE is able to detect changes in the mechanical properties of brain tissue resulting from kaolin-induced hydrocephalus, indicating the need for further study.

Citation Download Citation

Adam J. Pattison, S. Scott Lollis, Phillip R. Perríñez, John B. Weaver, and Keith D. Paulsen "MR elastography of hydrocephalus", Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 72620A (27 February 2009); https://doi.org/10.1117/12.811820

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