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Proceedings Article

Initial experimentation with in-line holography x-ray phase-contrast imaging with an ultrafast laser-based x-ray source

[+] Author Affiliations
Andrzej Krol

SUNY Upstate Medical Univ. and Syracuse Univ.

Russell Kincaid, Hongwei Ye, Edward Lipson

Syracuse Univ.

Marina Servol, Jean-Claude Kieffer, Remy Toth

INRS-EMT, Univ. du Québec (Canada)

Yakov Nesterets, Tim Gureyev, Andrew Stevenson, Steve Wilkins, Andrew Pogany

CSIRO Manufacturing and Materials Technology (Australia)

Ioana Coman

Ithaca College

Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 65100L (March 16, 2007); doi:10.1117/12.713634
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From Conference Volume 6510

  • Medical Imaging 2007: Physics of Medical Imaging
  • Jiang Hsieh; Michael J. Flynn
  • San Diego, CA | February 17, 2007

abstract

We have investigated experimentally and theoretically the imaging performance of our newly constructed in-line holography x-ray phase-contrast imaging system with an ultrafast laser-based x-ray source. Projection images of nylon fibers with diameters in the 10-330 μm range were obtained using an ultrafast (100 Hz, 28 fs, 40 mJ) laser-based x-ray source with Mo and Ta targets and Be filter, and Gaussian spatial-intensity distribution (FWHMS = 5 μm). A cooled CCD camera (24 μm pitch) with a Gd2OS2 screen coupled via 1:1 optical taper was used (FWHMD = 50 μm). We have investigated nylon-fiber image quality vs. imaging setup geometry and x-ray spectra. The following parameters were evaluated: contrast, signal-to-noise ratio (SNR), resolution, and sampling. In addition, we performed theoretical simulation of image formation for the same objects but within a wide range of geometrical parameters. The rigorous wave-optical formalism was used for modeling of the free-space propagation of x-rays from the object plane to the detector, and the "projection approximation" was used. We found reasonable agreement between predictions of our analytical model and the experiments. We conclude that: a) Optimum magnification maximizing contrast and SNR is almost independent of the source-to-detector (R ) distance and depends strongly on the diameter of the fiber. b) The corresponding maximum values of the contrast and SNR are almost linear with respect to R; the optimum magnification decreases with fiber diameter. c) The minimum diameter of fiber defines the minimum source-to-object distance R1 if R is fixed and the object is moved.

© (2007) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Andrzej Krol ; Russell Kincaid ; Marina Servol ; Jean-Claude Kieffer ; Yakov Nesterets, et al.
"Initial experimentation with in-line holography x-ray phase-contrast imaging with an ultrafast laser-based x-ray source", Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 65100L (March 16, 2007); doi:10.1117/12.713634; http://dx.doi.org/10.1117/12.713634


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