In vivo photoacoustic molecular imaging with targeting single-walled carbon nanotubes

Liangzhong Xiang; Da Xing; Yi Yuan; Lei Huang

doi:10.1117/12.822567

6 March 2009 In vivo photoacoustic molecular imaging with targeting single-walled carbon nanotubes

Liangzhong Xiang, Da Xing, Yi Yuan, Lei Huang

Proceedings Volume 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine; 728010 (2009) https://doi.org/10.1117/12.822567
Event: Photonics and Optoelectronics Meetings, 2008, Wuhan, China

Abstract

Here we present that single-walled carbon nanotubes(SWNT) coated with poly(ethylene glycol) (PEG) can be used as a contrast agent for photoacoustic molecular imaging. In vitro and in vivo experiments results show a good enhancement of the optical absorption by SWNT in photoacoustic imaging. The experimental results also show that a high contrast and a high efficient targeting of integrin α_vβ₃ positive U87 human glioblastoma tumours in mice could be achieved. This study suggests that photoacoustic molecular imaging with antibody functionalized SWNTs has the potential to be an effective early tumor diagnoses method.

Citation Download Citation

Liangzhong Xiang, Da Xing, Yi Yuan, and Lei Huang "In vivo photoacoustic molecular imaging with targeting single-walled carbon nanotubes", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 728010 (6 March 2009); https://doi.org/10.1117/12.822567

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KEYWORDS

Single walled carbon nanotubes

Photoacoustic spectroscopy

Molecular imaging

Tumors

In vivo imaging

Transducers

Photoacoustic imaging

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