Novel drug delivery strategies for porphyrins and porphyrin precursors

D. I. J. Morrow; R. F. Donnelly

doi:10.1117/12.822673

13 July 2009 Novel drug delivery strategies for porphyrins and porphyrin precursors

D. I. J. Morrow, R. F. Donnelly

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 738013 (2009) https://doi.org/10.1117/12.822673
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

superficial lesions, such as actinic keratosis. In addition, photodynamic antimicrobial chemotherapy (PACT) is attracting increasing interest for the treatment of infection. However, delivery strategies for topical PDT and PACT are still based on application of rather simplistic cream and solution formulations, with little consideration given to thermodynamics, targeting or the physicochemical properties of the active agent. Purpose-designed dosage forms for topical delivery of aminolevulinic acid or its esters include creams containing penetration enhancers and/or iron chelators, pressure sensitive patches and bioadhesive patches. Such systems aim to enhance drug delivery across the stratum corneum and keratinised debris overlying neoplastic lesions and improve subsequent protoporphyrin IX (PpIX) production. The alternative to using porphyrin precursors is the use of pre-formed photosensitisers. However, owing to their relatively high molecular weights, conventional topical application is not appropriate. Innovative strategies, such as the use of needle-free injections and microneedle arrays, bypass the stratum corneum, enabling rapid and targeted delivery not only porphyrin precursors but also pre-formed photosensitisers. This presentation will review drug delivery work published to date in the fields of PDT and PACT. In addition, the benefits of employing the latest advances in pharmaceutical technology will be highlighted.

Citation Download Citation

D. I. J. Morrow and R. F. Donnelly "Novel drug delivery strategies for porphyrins and porphyrin precursors", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738013 (13 July 2009); https://doi.org/10.1117/12.822673

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