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2 March 2010 Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) for the assessment of Pc 4-sensitized photodynamic therapy of a U87-derived glioma model in the athymic nude rat
Ali Anka, Paul Thompson, Eric Mott, Rahul Sharma, Ruozhen Zhang, Nathan Cross, Jiayang Sun, Chris A. Flask, Nancy L. Oleinick, David Dean
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Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75483X (2010) https://doi.org/10.1117/12.842232
Event: SPIE BiOS, 2010, San Francisco, California, United States
Abstract
Introduction: Dynamic Contrast-Enhanced-Magnetic Resonance Imaging (DCE-MRI) may provide a means of tracking the outcome of Pc 4-sensitized photodynamic therapy (PDT) in deeply placed lesions (e.g., brain tumors). We previously determined that 150 μL of gadolinium (Gd-DTPA) produces optimal enhancement of U87-derived intracerebral tumors in an athymic nude rat glioma model. We wish to determine how consistently DCE-MRI enhancement will detect an increase in Gd-enhancement of these tumors following Pc 4-PDT. Methods: We injected 2.5 x 105 U87 cells into the brains of 6 athymic nude rats. After 7-8 days pre-Pc 4 PDT peri-tumor DCE-MRI images were acquired on a 7.0T microMRI scanner before and after administration of 150 μL Gd. DCE-MRI scans were repeated on Days 11, 12, and 13 following Pc 4-PDT (Day 8 or 9). Results: Useful DCE-MRI data were obtained for these animals before and after Pc 4- PDT. In the pre-Pc 4-PDT DCE-MRI scans an average normalized peak Gd enhancement was observed in tumor tissue that was 1.297 times greater than baseline (0.035 Standard Error [SE]). The average normalized peak Gd enhancement in the tumor tissue in the scan following PDT (Day 11) was 1.537 times greater than baseline (0.036 SE), a statistically significant increase in enhancement (p = 0.00584) over the pre-PDT level. Discussion: A 150 μL Gd dose appears to provide an unambiguous increase in signal indicating Pc 4-PDT-induced necrosis of the U87-derived tumor. Our DCEMRI protocol may allow the development of a clinically robust, unambiguous, non-invasive technique for the assessment of PDT outcome.
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Ali Anka, Paul Thompson, Eric Mott, Rahul Sharma, Ruozhen Zhang, Nathan Cross, Jiayang Sun, Chris A. Flask, Nancy L. Oleinick, and David Dean "Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) for the assessment of Pc 4-sensitized photodynamic therapy of a U87-derived glioma model in the athymic nude rat", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75483X (2 March 2010); https://doi.org/10.1117/12.842232
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KEYWORDS
Tumors
Photodynamic therapy
Brain
Tissues
Neuroimaging
Gadolinium
Resonance enhancement
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