Localization of fluorescence marked prostate tumor with time-resolved diffuse optical tomography

Lionel Hervé; Aurélie Laidevant; Ludovic Lecordier; Laurent Guyon; Mathieu Debourdeau; Jérôme Boutet; Jean-Marc Dinten

doi:10.1117/12.840861

23 February 2010 Localization of fluorescence marked prostate tumor with time- resolved diffuse optical tomography

Lionel Hervé, Aurélie Laidevant, Ludovic Lecordier, Laurent Guyon, Mathieu Debourdeau, Jérôme Boutet, Jean-Marc Dinten

Proceedings Volume 7557, Multimodal Biomedical Imaging V; 75570F (2010) https://doi.org/10.1117/12.840861
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

To increase prostate cancer diagnosis sensibility, we propose to add an optical modality to an US biopsy tool to localize fluorophore marked tumors. Optical signals are acquired on a time-resolved acquisition chain composed by a 770 nm femtosecond laser source and a four channels TCSPC device. The fluorescence concentration is reconstructed by using intensity and mean time of flight acquired from each time-resolved source-detector signal. Validation experiments are performed on a phantom mimicking prostate both on its optical and ultrasound properties with 10 μmol/L ICG 1 cm deep double fluorescent inclusions to simulate marked tumors. An exhaustive search algorithm succeeded in reconstructing the two distinct fluorescence dots with correct locations.

Citation Download Citation

Lionel Hervé, Aurélie Laidevant, Ludovic Lecordier, Laurent Guyon, Mathieu Debourdeau, Jérôme Boutet, and Jean-Marc Dinten "Localization of fluorescence marked prostate tumor with time- resolved diffuse optical tomography", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570F (23 February 2010); https://doi.org/10.1117/12.840861

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