Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser

K. T. Tsen; Shaw-Wei D. Tsen; Q. Fu; S. M. Lindsay; K. Kibler; B. Jacobs; T. C. Wu; Zhe Li; Hao Yan; Stephanie Cope; Sara Vaiana; Juliann G. Kiang

doi:10.1117/12.841316

11 February 2010 Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser

K. T. Tsen, Shaw-Wei D. Tsen, Q. Fu, S. M. Lindsay, K. Kibler, B. Jacobs, T. C. Wu, Zhe Li, Hao Yan, Stephanie Cope, Sara Vaiana, Juliann G. Kiang

Author Affiliations +

Proceedings Volume 7561, Optical Biopsy VII; 75610W (2010) https://doi.org/10.1117/12.841316
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We report a photonic approach for selective inactivation of viruses with a near-infrared ultrashort pulsed (USP) laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as M13 bacteriophage, tobacco mosaic virus (TMV) to pathogenic viruses like human papillomavirus (HPV) and human immunodeficiency virus (HIV). At the same time sensitive materials like human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.

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K. T. Tsen, Shaw-Wei D. Tsen, Q. Fu, S. M. Lindsay, K. Kibler, B. Jacobs, T. C. Wu, Zhe Li, Hao Yan, Stephanie Cope, Sara Vaiana, and Juliann G. Kiang "Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser", Proc. SPIE 7561, Optical Biopsy VII, 75610W (11 February 2010); https://doi.org/10.1117/12.841316

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