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Proceedings Article

Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model

[+] Author Affiliations
Song Hu, Junjie Yao, Konstantin Maslov, Lihong V. Wang

Washington Univ. in St. Louis (USA)

Sunday Oladipupo, Andrea C. Santeford, Joanna Kovalski, Jeffrey M. Arbeit

Washington Univ. School of Medicine (USA)

Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756406 (February 23, 2010); doi:10.1117/12.841177
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From Conference Volume 7564

  • Photons Plus Ultrasound: Imaging and Sensing 2010
  • Alexander A. Oraevsky; Lihong V. Wang
  • San Francisco, California | January 23, 2010

abstract

A major obstacle in studying angiogenesis is the inability to noninvasively image neovascular development in an individual animal. We applied optical-resolution photoacoustic microscopy (OR-PAM) to determine the kinetics of hypoxia-inducible factor-1 (HIF-1)-mediated angiogenesis in a transgenic mouse model. During continuous 30-day activation of HIF-1α, we used OR-PAM to monitor alterations in microvasculature in transgenic mice compared to nontransgenic mice. OR-PAM has demonstrated the potential to precisely monitor antiangiogenic therapy of human cancers, allowing for rapid determinations of therapeutic efficacy or resistance.

© (2010) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Song Hu ; Sunday Oladipupo ; Junjie Yao ; Andrea C. Santeford ; Konstantin Maslov, et al.
"Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756406 (February 23, 2010); doi:10.1117/12.841177; http://dx.doi.org/10.1117/12.841177


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