Feasibility and methodology of optical coherence tomography imaging of human intracranial aneurysms: ex vivo pilot study

Barry Vuong; Cuiru Sun; Tim-Rasmus Khiel; Joseph A. Gardecki; Beau A. Standish; Leodante da Costa; Josaphat de Morais; Guillermo J. Tearney; Victor X. D. Yang

doi:10.1117/12.908998

17 February 2012 Feasibility and methodology of optical coherence tomography imaging of human intracranial aneurysms: ex vivo pilot study

Barry Vuong, Cuiru Sun, Tim-Rasmus Khiel, Joseph A. Gardecki, Beau A. Standish, Leodante da Costa, Josaphat de Morais, Guillermo J. Tearney, Victor X. D. Yang

Author Affiliations +

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82074M (2012) https://doi.org/10.1117/12.908998
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Rupture of intracranial aneurysm is a common cause of subarachnoid hemorrhage. An aneurysm may undergo microscopic morphological changes or remodeling of the vessel wall prior to rupture, which could potentially be imaged. In this study we present methods of tissue sample preparation of intracranial aneurysms and correlation between optical coherence tomography imaging and routine histology. OCT has a potential future in the assessment of microscopic features of aneurysms, which may correlate to the risk of rupture.

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Barry Vuong, Cuiru Sun, Tim-Rasmus Khiel, Joseph A. Gardecki, Beau A. Standish, Leodante da Costa, Josaphat de Morais, Guillermo J. Tearney, and Victor X. D. Yang "Feasibility and methodology of optical coherence tomography imaging of human intracranial aneurysms: ex vivo pilot study", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074M (17 February 2012); https://doi.org/10.1117/12.908998

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