0

Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

Selective, high-optrode-count, artifact-free stimulation with infrared light via intrafascicular Utah slanted optrode arrays

[+] Author Affiliations
Gregory A. Clark, Sylvana L. Schister, Noah M. Ledbetter, David J. Warren, Florian Solzbacher, Steven M. Blair, Loren W. Rieth, Prashant R. Tathireddy

The Univ. of Utah (USA)

Jonathon D. Wells, Matthew D. Keller

Lockheed Martin Aculight (USA)

Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82075I (February 9, 2012); doi:10.1117/12.907627
Text Size: A A A
From Conference Volume 8207

  • Photonic Therapeutics and Diagnostics VIII
  • San Francisco, California, USA | January 21, 2012

abstract

Here we present the first use of intraneural and intrafascicular infrared neural stimulation (INS) with early-generation Utah Slanted Optrode Arrays (USOAs) to produce highly selective, artifact-free stimulation of peripheral nerves. USOAs utilize technology previously developed for Utah Slanted Electrode Arrays, and contain 100 silicon optrodes of 0.5 to 1.5 mm length, spaced 400 μm apart in a 10 x 10 grid. The optrodes penetrate into the nerve and closely abut nerve fibers, thus providing multiple, independent, focal sites of stimulation. We first demonstrated that intraneural (but extrafascicular) infrared (IR) stimulation of cat sciatic nerve with conventional optical fibers coupled to a Lockheed Martin Aculight Capella laser produced stronger and more selective neural and muscle compound action potentials (CAPs) than did extraneural INS. We next tested INS through individual USOA optrodes (e.g., wavelength 1873 nm, 5- ms stimulus pulse, < 1 mJ at optrode tip). In contrast to extraneural INS, intrafascicular INS evoked relatively strong and highly selective, optrode-specific responses. Further, there were no observable stimulus artifacts, thereby allowing adjacent electrical recordings. These initial results indicate that intrafascicular INS via USOAs may provide a more efficient, more selective, high-optrode-count means of activating axons, plus greater access to interior nerve fibers.

© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Gregory A. Clark ; Sylvana L. Schister ; Noah M. Ledbetter ; David J. Warren ; Florian Solzbacher, et al.
"Selective, high-optrode-count, artifact-free stimulation with infrared light via intrafascicular Utah slanted optrode arrays", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82075I (February 9, 2012); doi:10.1117/12.907627; http://dx.doi.org/10.1117/12.907627


Access This Article
Sign In to Access Full Content
Please Wait... Processing your request... Please Wait.
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
 

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement


Buy this article ($18 for members, $25 for non-members).
Sign In