Non-contact photoacoustic tomography and ultrasonography for brain imaging

Guy Rousseau; Alain Blouin; Jean-Pierre Monchalin

doi:10.1117/12.906871

9 February 2012 Non-contact photoacoustic tomography and ultrasonography for brain imaging

Guy Rousseau, Alain Blouin, Jean-Pierre Monchalin

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 820750 (2012) https://doi.org/10.1117/12.906871
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Photoacoustic tomography (PAT) and ultrasonography (US) of biological tissues usually rely on transducer arrays for the detection of ultrasound. Obtaining the best sensitivity requires a physical contact with the tissue using an intermediate coupling fluid (water or gel). This type of contact is a major drawback for several applications such as neurosurgery. Laser-ultrasonics is an established optical technique for the non-contact generation and detection of ultrasound in industrial materials. In this paper, the non-contact detection scheme used in laser-ultrasonics is adapted to allow probing of ultrasound in biological tissues while remaining below laser exposure safety limits. Both non-contact PAT (NCPAT) and non-contact US (NCUS) are demonstrated experimentally using a single-frequency detection laser emitting suitably shaped pulses and a confocal Fabry-Perot interferometer. It is shown that an acceptable sensitivity is obtained while remaining below the maximum permissible exposure (MPE) of biological tissues. Results obtained ex vivo with a calf brain specimen show that sub-mm endogenous and exogenous inclusions can be detected at depths exceeding 1 cm. When fully developed, the technique could be a unique diagnostic tool in neurosurgery providing deep imaging of blood vessels, blood clots and blood oxygenation.

Citation Download Citation

Guy Rousseau, Alain Blouin, and Jean-Pierre Monchalin "Non-contact photoacoustic tomography and ultrasonography for brain imaging", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 820750 (9 February 2012); https://doi.org/10.1117/12.906871

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KEYWORDS

Tissues

Ultrasonography

Laser safety

Tissue optics

Natural surfaces

Ultrasonics

Biomedical optics

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