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Proceedings Article

Non-contact photoacoustic tomography and ultrasonography for brain imaging

[+] Author Affiliations
Guy Rousseau, Alain Blouin, Jean-Pierre Monchalin

National Research Council Canada (Canada)

Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 820750 (February 9, 2012); doi:10.1117/12.906871
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From Conference Volume 8207

  • Photonic Therapeutics and Diagnostics VIII
  • San Francisco, California, USA | January 21, 2012

abstract

Photoacoustic tomography (PAT) and ultrasonography (US) of biological tissues usually rely on transducer arrays for the detection of ultrasound. Obtaining the best sensitivity requires a physical contact with the tissue using an intermediate coupling fluid (water or gel). This type of contact is a major drawback for several applications such as neurosurgery. Laser-ultrasonics is an established optical technique for the non-contact generation and detection of ultrasound in industrial materials. In this paper, the non-contact detection scheme used in laser-ultrasonics is adapted to allow probing of ultrasound in biological tissues while remaining below laser exposure safety limits. Both non-contact PAT (NCPAT) and non-contact US (NCUS) are demonstrated experimentally using a single-frequency detection laser emitting suitably shaped pulses and a confocal Fabry-Perot interferometer. It is shown that an acceptable sensitivity is obtained while remaining below the maximum permissible exposure (MPE) of biological tissues. Results obtained ex vivo with a calf brain specimen show that sub-mm endogenous and exogenous inclusions can be detected at depths exceeding 1 cm. When fully developed, the technique could be a unique diagnostic tool in neurosurgery providing deep imaging of blood vessels, blood clots and blood oxygenation.

© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Guy Rousseau ; Alain Blouin and Jean-Pierre Monchalin
"Non-contact photoacoustic tomography and ultrasonography for brain imaging", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 820750 (February 9, 2012); doi:10.1117/12.906871; http://dx.doi.org/10.1117/12.906871


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