Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

Xiangyang Zhang; Jianming Hu; Robert W. Knighton; Xiang-Run Huang; Carmen A. Puliafito; Shuliang Jiao

doi:10.1117/12.909525

8 February 2012 Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

Xiangyang Zhang, Jianming Hu, Robert W. Knighton, Xiang-Run Huang, Carmen A. Puliafito, Shuliang Jiao

Author Affiliations +

Proceedings Volume 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI; 82130H (2012) https://doi.org/10.1117/12.909525
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

The ultimate goal of the study is to provide an imaging tool to detect the earliest signs of glaucoma before clinically visible damage occurs to the retinal nerve fiber layer (RNFL). Studies have shown that the optical reflectance of the damaged RNFL at short wavelength (<560nm) is reduced much more than that at long wavelength, which provides spectral contrasts for imaging the earliest damage to the RNFL. To image the spectral contrasts we built a dual-band spectral-domain optical coherence tomography (SD-OCT) with centered wavelength of 415nm (VIS) and 808nm (NIR), respectively. The light at the two bands was provided by the fundamental and frequency-doubled outputs of a broadband Ti: Sapphire laser. The depth resolutions of the VIS and NIR OCT systems are 12.2μm and 4.7μm in the air. The system was applied to imaging the rat retina in vivo. Significantly different appearances between the OCT cross sectional images at the two bands are observed. The experimental results showed that the dual-band OCT system is feasible for imaging the spectral contrasts of the RNFL.

Citation Download Citation

Xiangyang Zhang, Jianming Hu, Robert W. Knighton, Xiang-Run Huang, Carmen A. Puliafito, and Shuliang Jiao "Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer", Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82130H (8 February 2012); https://doi.org/10.1117/12.909525

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