In vivo combined photoacoustic and Doppler ultrasound imaging

Yan Jiang; Tyler Harrison; Alexander Forbrich; Roger J. Zemp

doi:10.1117/12.909157

23 February 2012 In vivo combined photoacoustic and Doppler ultrasound imaging

Yan Jiang, Tyler Harrison, Alexander Forbrich, Roger J. Zemp

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 822315 (2012) https://doi.org/10.1117/12.909157
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

The long-term goal of our research is to develop photoacoustic and Doppler ultrasound imaging methods for noninvasive estimation of the oxygen consumption rate (MRO₂) in vivo. Previously, we have demonstrated a combined photoacoustic and high-frequency Doppler ultrasound system and shown the feasibility of flow velocity and oxygen saturation (sO₂) estimation using double-ink flow phantoms. In this work, the results of in vitro sheep blood experiments are presented. Blood oxygen flux has been estimated at different sO2 levels and mean flow speeds, and the uncertainty of the measurement has been quantified. In vivo experiments have been performed on Swiss Webster mice to provide coregistered photoacoustic and Doppler flow images with imaging depths of ~2mm. Doppler bandwidth broadening technique has been used to obtain transverse flow velocity. The diameter of the blood vessel is ~500μm and the mean flow speed is 15cm/s. We are working towards sO₂ estimation in vivo and 3D oxygen consumption imaging of tumors at depths beyond OR-PAM.

Citation Download Citation

Yan Jiang, Tyler Harrison, Alexander Forbrich, and Roger J. Zemp "In vivo combined photoacoustic and Doppler ultrasound imaging", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 822315 (23 February 2012); https://doi.org/10.1117/12.909157

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KEYWORDS

Doppler effect

Oxygen

Blood

Ultrasonography

Photoacoustic spectroscopy

In vivo imaging

Doppler tomography

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