Tunable multi-wavelength resonance-Raman detection of bacteria and chemicals in complex environments

Jacob Grun; Jeffrey Bowles; David Gillis; Pratima Kunapareddy; Robert Lunsford; Charles K. Manka; Sergei Nikitin; Zheng Wang

doi:10.1117/12.863209

4 May 2010 Tunable multi-wavelength resonance-Raman detection of bacteria and chemicals in complex environments

Jacob Grun, Jeffrey Bowles, David Gillis, Pratima Kunapareddy, Robert Lunsford, Charles K. Manka, Sergei Nikitin, Zheng Wang

Author Affiliations +

Proceedings Volume 7687, Active and Passive Signatures; 768706 (2010) https://doi.org/10.1117/12.863209
Event: SPIE Defense, Security, and Sensing, 2010, Orlando, Florida, United States

Abstract

We are developing tunable-multi-wavelength resonance-Raman spectroscopy and algorithms to enable rapid detection and identification of bacteria and chemicals in complex environments. The system, dubbed SWOrRD, is capable of illuminating a sample containing many chemicals or biological agents with a sequence of laser wavelengths between 210nm and 2000nm; a range which encompasses the resonant frequencies of cells, microorganisms, cellular metabolites, and many chemicals; and measures the resonance-Raman spectra of light scattered from the sample at each laser wavelength. These multiple spectra, which contain much more information about the bond structure that is contained in a single spectrum, are analyzed by a linear-mixture algorithm, based on NRL's ORASIS, to determine the chemical and bacteriological constituents of the sample. The current status of the research will be described.

Citation Download Citation

Jacob Grun, Jeffrey Bowles, David Gillis, Pratima Kunapareddy, Robert Lunsford, Charles K. Manka, Sergei Nikitin, and Zheng Wang "Tunable multi-wavelength resonance-Raman detection of bacteria and chemicals in complex environments", Proc. SPIE 7687, Active and Passive Signatures, 768706 (4 May 2010); https://doi.org/10.1117/12.863209

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