Water-soluble phthalocyanine complexes of Ga(III) and In(III) in the photodynamic inactivation of pathogenic fungus

V. Mantareva; I. Angelov; D. Wöhrle; V. Dogandjiska; R. Dimitrov; V. Kussovski

doi:10.1117/12.882065

17 January 2011 Water-soluble phthalocyanine complexes of Ga(III) and In(III) in the photodynamic inactivation of pathogenic fungus

V. Mantareva, I. Angelov, D. Wöhrle, V. Dogandjiska, R. Dimitrov, V. Kussovski

Author Affiliations +

Proceedings Volume 7747, 16th International School on Quantum Electronics: Laser Physics and Applications; 774712 (2011) https://doi.org/10.1117/12.882065
Event: XVI International School on Quantum Electronics: Laser Physics and Applications, 2010, Nessebar, Bulgaria

Abstract

Phthalocyanines of gallium(III) and indium(III) (GaPc1 and InPc1) bearing four methylpyridyloxy groups on the periphery of the phthalocyanine ring were synthesized. The both phthalocyanines were obtained with a good solubility in water solutions, which make them suitable for application in the Photodynamic therapy (PDT). The absorbance in the Uv-vis region of the complexes is typical for MPc with a highly intensive maximum in the far red spectra (681 nm - 697 nm for GaPc1 and for InPc1, both in DMSO). The fluorescence maxima are red shifted (691 nm/716 nm). The fluorescence quantum yields of the both complexes are lower than that for the unsubstituted MPcs with values of 0.25 for GaPc1 and much lower for InPc1 (0.012), which suggested a quenching from the substituents. The photochemical properties of singlet oxygen generation show quenching curves of "Furane" test with a ¹O₂ formation that increase significantly in the presence of the heavy atoms such as Ga(III) and especially In(III). Photodynamic efficacy against C. albicans in planktonic media was evaluated with a high photodynamic effect for GaPc1 at low concentrations (0.5 μM, - 3 μM) at mild irradiation parameters (30-60 J cm^-2 and 50 mW cm^-2). The inactivation of the fungus cells with InPc1 was insignificant even at strong treatment conditions (6.8 μM; 60 J cm^-2). The water-soluble phthalocyanine complexes of Ga(III) and In (III) were compared to the recently studied by us water-soluble Zn(II)-phthalocyanine, which was shown to have a high potential for photodynamic inactivation of variety pathogenic bacterial strains.

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V. Mantareva, I. Angelov, D. Wöhrle, V. Dogandjiska, R. Dimitrov, and V. Kussovski "Water-soluble phthalocyanine complexes of Ga(III) and In(III) in the photodynamic inactivation of pathogenic fungus", Proc. SPIE 7747, 16th International School on Quantum Electronics: Laser Physics and Applications, 774712 (17 January 2011); https://doi.org/10.1117/12.882065

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