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Proceedings Article

Direct imaging the subcellular localization of single-walled carbon nanotubes

[+] Author Affiliations
Feifan Zhou, Da Xing

MOE Key Lab. of Laser Life Science & Institute of Laser Life Science, South China Normal Univ. (China)

Wei R. Chen

MOE Key Lab. of Laser Life Science & Institute of Laser Life Science, South China Normal Univ. (China) and Univ. of Central Oklahoma (USA)

Proc. SPIE 7900, Biophotonics and Immune Responses VI, 79000E (February 10, 2011); doi:10.1117/12.874307
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From Conference Volume 7900

  • Biophotonics and Immune Responses VI
  • Wei R. Chen
  • San Francisco, California, USA | January 22, 2011

abstract

The development of single-walled carbon nanotubes (SWNTs) for various biomedical applications is an area of great promise. However, the contradictory data on the interaction of single-walled carbon nanotubes with cells highlight the need to study their uptake and cytotoxic effects in cells. Here, we use confocal microscopy to image the translocation of single-walled carbon nanotubes into cells and localization on the subcellular organelle. We also observe that single-walled carbon nanotubes do not affect the cellular condition and mitochondrial membrane potential. One intrinsic property of single-walled carbon nanotubes is their strong optical absorbance in the near-infrared (NIR) region. It could be used to selectively increase the thermal destructions in the target tumors. A specific type of SWNT by the CoMoCAT method has an intense absorption band at 980 nm. When irradiated with a 980-nm laser, the single-walled carbon nanotubes affect the cellular oxidation and destroy the mitochondrial membrane potential, and induce cell apoptosis. Thus, the single-walled carbon nanotubes appear to enter the cytoplasm without cytotoxic effects in cells, and can be used as effective and selective nanomaterials for cancer photothermal therapy.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Feifan Zhou ; Da Xing and Wei R. Chen
"Direct imaging the subcellular localization of single-walled carbon nanotubes", Proc. SPIE 7900, Biophotonics and Immune Responses VI, 79000E (February 10, 2011); doi:10.1117/12.874307; http://dx.doi.org/10.1117/12.874307


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