Activation of JNK/Bim/Bax pathway in UV-induced apoptosis

Lei Liu; Li Hui; Zhen-zhen Zhang

doi:10.1117/12.874749

22 February 2011 Activation of JNK/Bim/Bax pathway in UV-induced apoptosis

Lei Liu, Li Hui, Zhen-zhen Zhang

Proceedings Volume 7900, Biophotonics and Immune Responses VI; 79000I (2011) https://doi.org/10.1117/12.874749
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Cell apoptosis induced by UV irradiation is a highly complex process in which different molecular signaling pathways are involved. JNK has been proposed as an important regulator in UV irradiation-induced apoptosis. However, the molecular mechanism through which JNK regulates apoptosis, especially how JNK activates Bax in response to UV irradiation is still controversial. In this study, using real-time single-cell analysis, we studied the machinery of Bax activation during UV-induced apoptosis. UV treatment resulted in a series of events: phosphorylation of JNK, mitochondrial translocation of Bim, and subsequent activation of Bax. The activation of Bim and Bax could be inhibited in the presence of SP600125 (a specific inhibitor of JNK), suggesting that UV irradiation activated the JNK/Bim/Bax pathway.

Citation Download Citation

Lei Liu, Li Hui, and Zhen-zhen Zhang "Activation of JNK/Bim/Bax pathway in UV-induced apoptosis", Proc. SPIE 7900, Biophotonics and Immune Responses VI, 79000I (22 February 2011); https://doi.org/10.1117/12.874749

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