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Proceedings Article

The potential role of functional inhibition of T regulatory cells by anti-TGFβ antibody in photodynamic therapy of renal cancer

[+] Author Affiliations
Pawel Mroz

Wellman Ctr. for Photomedicine, Massachusetts General Hospital (USA) and Harvard Medical School (USA)

Michael R. Hamblin

Wellman Ctr. for Photomedicine, Massachusetts General Hospital (USA) and Harvard Medical School (USA) and Harvard-MIT Division of Health Sciences and Technology (USA)

Proc. SPIE 7900, Biophotonics and Immune Responses VI, 790003 (February 08, 2011); doi:10.1117/12.876523
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From Conference Volume 7900

  • Biophotonics and Immune Responses VI
  • Wei R. Chen
  • San Francisco, California, USA | January 22, 2011

abstract

Photodynamic therapy (PDT) has been shown to be an effective locally ablative anti-cancer treatment that has the additional advantage of inducing tumor-directed immune response. We hypothesized that PDT could be combined with anti-transforming growth factor (TGF) beta antibody that does not significantly affect the population of cytotoxic T lymphocytes (CTL) but at the same time, has the potential to decrease the immunosuppressive effects of regulatory T-cells (Treg) mediated by TGF beta. This hypothesis was tested with aTGF-beta antibody combined with BPD-mediated PDT in a BALB/c renal cell carcinoma model. Evidence of positive benefits of the combination therapy over individual treatments alone was obtained.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Pawel Mroz and Michael R. Hamblin
"The potential role of functional inhibition of T regulatory cells by anti-TGFβ antibody in photodynamic therapy of renal cancer", Proc. SPIE 7900, Biophotonics and Immune Responses VI, 790003 (February 08, 2011); doi:10.1117/12.876523; http://dx.doi.org/10.1117/12.876523


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