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Proceedings Article

Arrhenius parameters for primary thermal injury in human tonsillar tissue

[+] Author Affiliations
Kathleen McMillan

gRadiant Research, LLC (USA)

Rebecca Radabaugh, James E. Coad

West Virginia Univ. (USA)

Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 790110 (February 22, 2011); doi:10.1117/12.876338
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From Conference Volume 7901

  • Energy-based Treatment of Tissue and Assessment VI
  • Thomas P. Ryan
  • San Francisco, California, USA | January 22, 2011

abstract

Clinical implementation of a thermal therapy requires the ability to predict tissue injury following exposures to specific thermal histories. As part of an effort to develop a nonexcisional alternative to tonsillectomy, the degree of primary hyperthermic tissue injury in human tonsil was characterized. Fifteen fresh pediatric hypertrophic tonsillectomy specimens were sectioned and treated in a NIST-calibrated saline bath at temperatures of 40 to 70°C with hold times of one to seven minutes. The treated tissues were subsequently nitroblue tetrazolium (NBT) stained to assess for thermal respiratory enzyme inactivation as a marker of cellular injury/death. The NBT stains were quantitatively image analyzed and used to calculate Arrhenius parameters for primary thermal injury in human tonsils.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Topics

Injuries ; Tissues
Citation

Kathleen McMillan ; Rebecca Radabaugh and James E. Coad
"Arrhenius parameters for primary thermal injury in human tonsillar tissue", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 790110 (February 22, 2011); doi:10.1117/12.876338; http://dx.doi.org/10.1117/12.876338


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