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Proceedings Article

Intrinsic optical signal imaging of glucose-stimulated physiological responses in the insulin secreting INS-1 β-cell line

[+] Author Affiliations
Yi-Chao Li, Wan-Xing Cui, Xu-Jing Wang, Franklin Amthor, Xin-Cheng Yao

The Univ. of Alabama at Birmingham (USA)

Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 79070Y (February 11, 2011); doi:10.1117/12.874989
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From Conference Volume 7907

  • Biomedical Applications of Light Scattering V
  • Adam P. Wax; Vadim Backman
  • San Francisco, California, USA | January 22, 2011

abstract

Intrinsic optical signal (IOS) imaging has been established for noninvasive monitoring of stimulus-evoked physiological responses in the retina and other neural tissues. Recently, we extended the IOS imaging technology for functional evaluation of insulin secreting INS-1 cells. INS-1 cells provide a popular model for investigating β-cell dysfunction and diabetes. Our experiments indicate that IOS imaging allows simultaneous monitoring of glucose-stimulated physiological responses in multiple cells with high spatial (sub-cellular) and temporal (sub-second) resolution. Rapid image sequences reveal transient optical responses that have time courses comparable to glucose-evoked β-cell electrical activities.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Yi-Chao Li ; Wan-Xing Cui ; Xu-Jing Wang ; Franklin Amthor and Xin-Cheng Yao
"Intrinsic optical signal imaging of glucose-stimulated physiological responses in the insulin secreting INS-1 β-cell line", Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 79070Y (February 11, 2011); doi:10.1117/12.874989; http://dx.doi.org/10.1117/12.874989


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