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Proceedings Article

Size- and structure-dependent toxicity of silica particulates

[+] Author Affiliations
Sanshiro Hanada, Akiyoshi Hoshino, Kenji Yamamoto

National Ctr. for Global Health and Medicine (Japan)

Kenichi Miyaoi

Univ. Tokyo (Japan)

Susumu Inasawa, Yukio Yamaguchi

The Univ. of Tokyo (Japan)

Proc. SPIE 7909, Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI, 79090A (February 11, 2011); doi:10.1117/12.874477
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From Conference Volume 7909

  • Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI
  • Wolfgang J. Parak; Kenji Yamamoto; Marek Osinski
  • San Francisco, California, USA | January 22, 2011

abstract

Nano- and micro-particulates firmly attach with the surface of various biological systems. In some chronic pulmonary disease such as asbestosis and silicosis, causative particulates will induce chronic inflammatory disorder, followed by poor prognosis diseases. However, nano- and micro-scale specific toxicity of silica particulates is not well examined enough to recognize the risk of nano- and micro-particulates from the clinical aspect. To clarify the effect of the size and structure of silica particulates on the cellular damage and the biological response, we assessed the cytotoxicity of the various kinds of silica particles including amorphous and crystalline silica, in mouse alveolar macrophage culture, focusing on the fibrotic and inflammatory response. Our study showed that the cytotoxicity, which depends on the particle size and surface area, is correlated with their inflammatory response. By contrast, production of TGF-β, which is one of the fibrotic agents in lung, by addition of crystal silica was much higher than that of amorphous silica. We conclude that fibrosis and inflammation are induced at different phases and that the size- and structure-differences of silica particulates affect the both biological responses, caused by surface activity, radical species, and so on.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Sanshiro Hanada ; Kenichi Miyaoi ; Akiyoshi Hoshino ; Susumu Inasawa ; Yukio Yamaguchi, et al.
"Size- and structure-dependent toxicity of silica particulates", Proc. SPIE 7909, Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI, 79090A (February 11, 2011); doi:10.1117/12.874477; http://dx.doi.org/10.1117/12.874477


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