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Proceedings Article

Effect of nano-encapsulation on photophysical properties of ICG

[+] Author Affiliations
Sharad Gupta, Kumar Thenkondar, Hardik Mehta, Baharak Bahmani, Valentine Vullev, Bahman Anvari

Univ. of California, Riverside (USA)

Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79100U (February 15, 2011); doi:10.1117/12.875669
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From Conference Volume 7910

  • Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
  • Samuel Achilefu; Ramesh Raghavachari
  • San Francisco, California, USA | January 22, 2011

abstract

Indocyanine green (ICG) is an FDA-approved infrared chromophore used for various biomedical applications such as cardiac and hepatic function evaluation, and ophthalmic angiography. Despite its clinical applications, freely dissolved ICG binds non-specifically to various plasma proteins resulting in changes in its near infrared (NIR) emission properties and rapid elimination from the vasculature. To overcome these shortcomings, we have encapsulated ICG within polymeric nano-constructs composed of poly allylamine hydrochloride (PAH) cross-linked with di-sodium hydrogen phosphate (Na2HPO4). To optimize the photophysical properties of nano-encapsulated ICG (NE-ICG) for clinical imaging applications, we report measurements of fluorescent quantum yield (φ) of NE-ICG. Specifically, we constructed capsules of three different diameters (~130, ~240, and ~450 nm). Our preliminary results indicate that NE-ICG shows less quantum yield compared to freely-dissolved ICG. We determined that the 240 nm diameter capsule to have the highest φ and 450 nm diameter capsules to have the least φ at room temperature.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Sharad Gupta ; Kumar Thenkondar ; Hardik Mehta ; Baharak Bahmani ; Valentine Vullev, et al.
"Effect of nano-encapsulation on photophysical properties of ICG", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79100U (February 15, 2011); doi:10.1117/12.875669; http://dx.doi.org/10.1117/12.875669


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