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Proceedings Article

Protein nanospheres: synergistic nanoplatform-based probes for multimodality imaging

[+] Author Affiliations
Michael A. McDonald

National Institute of Standards and Technology (USA)

Paul C. Wang

Howard Univ. (USA)

Eliot L. Siegel

Univ. of Maryland (USA)

Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101G (February 21, 2011); doi:10.1117/12.876081
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From Conference Volume 7910

  • Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
  • Samuel Achilefu; Ramesh Raghavachari
  • San Francisco, California, USA | January 22, 2011

abstract

No single clinical imaging modality has the ability to provide both high resolution and high sensitivity at the anatomical, functional and molecular level. Synergistically integrated detection techniques overcome these barriers by combining the advantages of different imaging modalities while reducing their disadvantages. We report the development of protein nanospheres optimized for enhancing MRI, CT and US contrast while also providing high sensitivity optical detection. Transferrin protein nanospheres (TfpNS), silicon coated, doped rare earth oxide and rhodamine B isothiocyanate nanoparticles, Si⊂Gd2O3:Eu,RBITC, (NP) and transferrin protein nanospheres encapsulating Si⊂Gd2O3:Eu,RBITC nanoparticles (TfpNS-NP) were prepared in tissue-mimicking phantoms and imaged utilizing multiple cross-sectional imaging modalities. Preliminary results indicate a 1:1 NP to TfpNS ratio in TfpNS-NP and improved sensitivity of detection for MRI, CT, US and fluorescence imaging relative to its component parts and/or many commercially available contrast agents.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Michael A. McDonald ; Paul C. Wang and Eliot L. Siegel
"Protein nanospheres: synergistic nanoplatform-based probes for multimodality imaging", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101G (February 21, 2011); doi:10.1117/12.876081; http://dx.doi.org/10.1117/12.876081


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