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Proceedings Article

Storable near-infrared chemiluminescent probes for in vivo optical imaging

[+] Author Affiliations
Bradley D. Smith

Univ. of Notre Dame (USA)

Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791013 (February 11, 2011); doi:10.1117/12.876709
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From Conference Volume 7910

  • Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
  • Samuel Achilefu; Ramesh Raghavachari
  • San Francisco, California, USA | January 22, 2011

abstract

A new class of chemiluminescent and fluorescent dyes and dye-doped nanoparticles can be stored at zero degrees and then made to emit near-infrared light by warming to body temperature (no chemical or electrical stimulus is needed). In vivo chemiluminescence imaging permits identification of target sites that are five times deeper than planar fluorescence imaging. A new imaging paradigm employs the dual modality probes first in high contrast chemiluminescence mode to locate relatively deep anatomical locations in vivo and subsequently in fluorescent mode to identify the microscopic targets within thin histopathology sections taken from the same specimen.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Bradley D. Smith
"Storable near-infrared chemiluminescent probes for in vivo optical imaging", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791013 (February 11, 2011); doi:10.1117/12.876709; http://dx.doi.org/10.1117/12.876709


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