The paper reports about the results of researches of nanopowder production with a help powerful repetitively pulsed CO2 laser "LAERT" which generated radiation with pulse energy of ≈1 J, peak power of ≈8 kW and mean power of 500 W. Laser radiation affected and evaporated the target. The target material vapor condensed into nanoparticles as a result of intermixing vapor with a flow of cold gas. In basic the air of atmospheric pressure was used as the carrier gas. However in some experiments were used He and Ar and the gas pressure also was changed. In our experiments we produced nanopowders of such materials as: YSZ, YSZ:Al2O3, Al2O3, CeO2:Gd2O3, 0.5%Nd:Y2O3, 1%Nd:YAG, Fe3O4and carbon with a middle size 10÷30 nm. Received nanopowders were also weakly agglomerated. We carried out 3D numerical modeling of thermo-hydrodynamic processes occurred during the laser evaporation of a target. Results of calculations have cleared up many details of target evaporation. In particular, influence of liquid melt movement on stoichiometry of evaporation of a target from oxide mixes is found out. Results of calculations are in a good agreement with experimental data.© (2010) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.