The influence of laser radiation is one of the means of changing the microstructure, physical properties of solids and stabilizing metastable states. In this work we investigate the influence of laser radiation on surface morphology, composition and electrical conduction of copper oxide ceramic samples. The samples were synthesized under different conditions; part of them was covered by copper film and subjected to additional thermal treatment. The laser processing of crystal surfaces was carried out by the radiation by the second and third harmonics of a YAG:Nd laser. We have studied the temperature dependence of resistivity and the volt-ampere characteristics of the samples within the 77-300 K temperature range. In some of the samples we have observed HTSC-like drop of resistivity at ≤ 250 K temperatures.© (2010) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.