Optoelectronical components and devices based on organic materials offer a wealth of possibilities in terms of integration, miniaturization and potentially low-cost fabrication for relevant applications, notwithstanding a performance that may fall short of conventional state-of-the-art systems. In this context we report on progress towards the combination of surface plasmon resonance (SPR) sensing with a monolithically integrated optical sensor platform based on organic materials, including an organic light emitting diode, an optical polymer waveguide and an organic photo diode. Several according components have been developed and demonstrated recently and were exemplarily applied to fluorescence lifetime detection. Aiming at multianalyte performance we add SPR to this platform, which enables the sensitive, real-time and label-free detection of a wide range of analytes. The SPR detection scheme is based on a gold surface sustaining a surface plasmon mode which reacts sensitively to analyte-induced refractive index changes. Here, we report on the investigation of the sensor response of a 50 nm thick gold film on an 11 μm thick multimode polymer waveguide. The feasibility of this sensor concept is shown and its sensitivity is estimated from measuring the intensity transmitted trough the waveguide at a single wavelength. In addition, some further steps towards full integration are discussed.© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.