GRIN microendoscopes for high resolution in-vivo fluorescence imaging in small animals

Jun Ki Kim; Seok-Hyun Yun

doi:10.1117/12.970382

17 October 2012 GRIN microendoscopes for high resolution in-vivo fluorescence imaging in small animals

Jun Ki Kim, Seok-Hyun Yun

Proceedings Volume 8421, OFS2012 22nd International Conference on Optical Fiber Sensors; 84211P (2012) https://doi.org/10.1117/12.970382
Event: OFS2012 22nd International Conference on Optical Fiber Sensor, 2012, Beijing, China

Abstract

Intravital imaging of small animal models is a powerful technique in basic and preclinical studies. Due to the physical size of conventional microscope optics, there is a need to carry out extensive surgery procedures so as to expose tissues of an organ during each imaging session. This limits the length of time and periodicity of each imaging session for the same animal, thus results in low experimental throughput. Advancements in micro-optics and fiber optics technology have paved way in removing such physical constraints. In this study, we fabricate high quality micro-endoscope based on graded-index lenses for carrying out minimally invasive imaging procedures in live animals.

Citation Download Citation

Jun Ki Kim and Seok-Hyun Yun "GRIN microendoscopes for high resolution in-vivo fluorescence imaging in small animals", Proc. SPIE 8421, OFS2012 22nd International Conference on Optical Fiber Sensors, 84211P (17 October 2012); https://doi.org/10.1117/12.970382

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