Singlet oxygen dosimetry modeling for photodynamic therapy

Xing Liang; Ken Kang-hsin Wang; Timothy C. Zhu

doi:10.1117/12.908317

9 March 2012 Singlet oxygen dosimetry modeling for photodynamic therapy

Xing Liang, Ken Kang-hsin Wang, Timothy C. Zhu

Proceedings Volume 8210, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI; 82100T (2012) https://doi.org/10.1117/12.908317
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Photodynamic therapy (PDT) is an important treatment modality for cancer and other localized diseases. In addition to PDT dose, singlet oxygen (¹O₂) concentration is used as an explicit PDT dosimetry quantity, because ¹O₂ is the major cytotoxic agent in photodynamic therapy, and the reaction between ¹O₂ and tumor tissues/cells determines the treatment efficacy. ¹O₂ concentration can be obtained by the PDT model, which includes diffusion equation for the light transport in tissue and macroscopic kinetic equations for the generation of the singlet oxygen. This model was implemented using finite-element method (FEM) by COMSOL. In the kinetic equations, 5 photo-physiological parameters were determined explicitly to predict the generation of ¹O₂. The singlet oxygen concentration profile was calculated iteratively by comparing the model with the measurements based on mice experiments, to obtain the apparent reacted ¹O₂concentration as an explicit PDT dosimetry quantity. Two photosensitizers including Photofrin and BPD Verteporfin, were tested using this model to determine their photo-physiological parameters and the reacted ¹O₂ concentrations.

Citation Download Citation

Xing Liang, Ken Kang-hsin Wang, and Timothy C. Zhu "Singlet oxygen dosimetry modeling for photodynamic therapy", Proc. SPIE 8210, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI, 82100T (9 March 2012); https://doi.org/10.1117/12.908317

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