Breast cancer in tough economic times: disruptive technology emerging

Phillip Bretz M.D.; Richard Lynch

doi:10.1117/12.921368

18 May 2012 Breast cancer in tough economic times: disruptive technology emerging

Phillip Bretz M.D., Richard Lynch

Proceedings Volume 8354, Thermosense: Thermal Infrared Applications XXXIV; 83540V (2012) https://doi.org/10.1117/12.921368
Event: SPIE Defense, Security, and Sensing, 2012, Baltimore, Maryland, United States

Abstract

The objective of this study was to investigate the efficacy of melding three emerging technologies: Pharmacogenomics, Modified Military Digital Infrared and Halo to establish their capability in diagnosing ultra-small breast cancers as well as other cancers. Mammography, ultrasound and MRI technologies have been available for over forty years, however, there is still no uniform utilization by women, costs continue to escalate and problems persist like high false positive rates for MRI and high false negative rates for mammography. Of the first 500 IR patients, 499 were female and 1 male. Of 550 OncoVue patients, 129 opted to undergo IR. A total of 19 were lost to follow-up. Patients who were negative on IR: 419/500 (84%). Of these, 63/419 went to biopsy because of findings of other diagnostic modalities. Of these 61/63 with negative IR had a negative biopsy. Of two missed, one was the fault of the investigator but was included. In this series 2/500 were false negative (0.4%). The sensitivity was 96% and the specificity was 79%. In total, 46 cancers were identified including five outside the breast (e.g. 2 lung cancers). A total of 92 MRIs were done and in 71/92 patients IR and MRI agreed. Using these three modalities the smallest cancer found was a 4 mm invasive cancer. The study demonstrated that these diagnostic techniques can dramatically lower cost and provide results at least as good as the older paradigms. Further research and a multicenter clinical trial are necessary to shift the paradigm of breast cancer diagnosis and treatment.

Citation Download Citation

Phillip Bretz M.D. and Richard Lynch "Breast cancer in tough economic times: disruptive technology emerging", Proc. SPIE 8354, Thermosense: Thermal Infrared Applications XXXIV, 83540V (18 May 2012); https://doi.org/10.1117/12.921368

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
21 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Breast cancer

Infrared radiation

Cancer

Mammography

Breast

Magnetic resonance imaging

Biopsy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years