Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

Multiscale regularized reconstruction for enhancing microcalcification in digital breast tomosynthesis

[+] Author Affiliations
Yao Lu, Heang-Ping Chan, Jun Wei, Lubomir Hadjiiski, Chuan Zhou

Univ. of Michigan (United States)

Proc. SPIE 8313, Medical Imaging 2012: Physics of Medical Imaging, 831322 (February 23, 2012); doi:10.1117/12.912573
Text Size: A A A
From Conference Volume 8313

  • Medical Imaging 2012: Physics of Medical Imaging
  • Norbert J. Pelc; Robert M. Nishikawa; Bruce R. Whiting
  • San Diego, California, USA | February 04, 2012

abstract

Digital breast tomosynthesis (DBT) holds strong promise for improving the sensitivity of detecting subtle mass lesions. Detection of microcalcifications is more difficult because of high noise and subtle signals in the large DBT volume. It is important to enhance the contrast-to-noise ratio (CNR) of microcalcifications in DBT reconstruction. A major challenge of implementing microcalcification enhancement or noise regularization in DBT reconstruction is to preserve the image quality of masses, especially those with ill-defined margins and subtle spiculations. We are developing a new multiscale regularization (MSR) method for the simultaneous algebraic reconstruction technique (SART) to improve the CNR of microcalcifications without compromising the quality of masses. Each DBT slice is stratified into different frequency bands via wavelet decomposition and the regularization method applies different degrees of regularization to different frequency bands to preserve features of interest and suppress noise. Regularization is constrained by a characteristic map to avoid smoothing subtle microcalcifications. The characteristic map is generated via image feature analysis to identify potential microcalcification locations in the DBT volume. The MSR method was compared to the non-convex total pvariation (TpV) method and SART with no regularization (NR) in terms of the CNR and the full width at half maximum of the line profiles intersecting calcifications and mass spiculations in DBT of human subjects. The results demonstrated that SART regularized by the MSR method was superior to the TpV method for subtle microcalcifications in terms of CNR enhancement. The MSR method preserved the quality of subtle spiculations better than the TpV method in comparison to NR.© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Yao Lu ; Heang-Ping Chan ; Jun Wei ; Lubomir Hadjiiski and Chuan Zhou
"Multiscale regularized reconstruction for enhancing microcalcification in digital breast tomosynthesis", Proc. SPIE 8313, Medical Imaging 2012: Physics of Medical Imaging, 831322 (February 23, 2012); doi:10.1117/12.912573; http://dx.doi.org/10.1117/12.912573


Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.