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Proceedings Article

Tight neurovascular coupling in a rat model of quasi-periodic interictal spiking using multispectral optical imaging

[+] Author Affiliations
Philippe Pouliot, Van Tri Truong, Cong Zhang, Simon Dubeau, Frédéric Lesage

Ecole Polytechnique de Montréal (Canada)

Proc. SPIE 8412, Photonics North 2012, 841203 (October 23, 2012); doi:10.1117/12.2000717
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From Conference Volume 8412

  • Photonics North 2012
  • Jean-Claude Kieffer
  • Montreal, Canada | June 06, 2012

abstract

The hemodynamic responses to 4-aminopyridine (4-AP) induced focal epileptic spikes and electrical stimulations are compared in a rat model. Nonlinearities are quantified with biophysical models. Supranormal oxygen consumption from epileptic spikes is inferred. In one recording, interictal spikes followed an almost periodic pattern. Such rhythmic spiking is a well-documented phenomenon in electrophysiological studies, but the hemodynamics correlates have been less studied. Spikes occurred every 12.5 ± 1.0 s. Peaks in total hemoglobin (HbT), a proxy for regional cerebral blood volume, followed spikes by 2.6 ± 0.3 s. Troughs in HbT preceded spikes by 1.68 ± 1.2 s. The narrowness of this distribution is surprising. From it, one may derive a significant but paradoxical fall in HbT several seconds before the spikes, but which this decrease in HbT is better interpreted as being due to the interictal spike that occurred before. © (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Philippe Pouliot ; Van Tri Truong ; Cong Zhang ; Simon Dubeau and Frédéric Lesage
" Tight neurovascular coupling in a rat model of quasi-periodic interictal spiking using multispectral optical imaging ", Proc. SPIE 8412, Photonics North 2012, 841203 (October 23, 2012); doi:10.1117/12.2000717; http://dx.doi.org/10.1117/12.2000717


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