Properties of herbal extracts against Propionibacterium acnes for biomedical application

Youn-Mook Lim; Sung Eun Kim; Yong Soo Kim; Young Min Shin; Sung In Jeong; Sun-Young Jo; Hui-Jeong Gwon; Jong-seok Park; Young-Chang Nho; Jong-Cheol Kim; Seong-Jang Kim; HeungSoo Shin

doi:10.1117/12.2000074

24 October 2012 Properties of herbal extracts against Propionibacterium acnes for biomedical application

Youn-Mook Lim, Sung Eun Kim, Yong Soo Kim, Young Min Shin, Sung In Jeong, Sun-Young Jo, Hui-Jeong Gwon, Jong-seok Park, Young-Chang Nho, Jong-Cheol Kim, Seong-Jang Kim, HeungSoo Shin

Author Affiliations +

Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 854849 (2012) https://doi.org/10.1117/12.2000074
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of

Abstract

Propionibacterium acnes (P. acnes), one of the anaerobic bacterium, causes inflammatory acne. To find a novel medication for treating the inflammation caused by P. acnes, we investigated the anti-bacterial and anti-inflammatory activities of several herbal extracts against P. acnes. The aqueous extracts from five dried herbs, Phellodendron amurense Rupr., Paeonia lactiflora Pallas., Houttuynia cordata Thunb., Agrimonia pilosa Ledeb. and Glycyrrhiza uralensis Fisch., were prepared and mixed. In this experiment, 1 mg/ml of the herbal extract mixture caused a decrease in the growth of P. acnes and reduced the production of pro-inflammatory cytokines, TNF-α, IL-8, IL-1β and IL-6, in human monocytic THP-1 cells treated with heat-killed P. acnes. Therefore, this herbal extract mixture may possess both anti-bacterial and anti-inflammatory activities against P. acnes and can be a novel therapeutic agent for treating inflammatory acne.

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Youn-Mook Lim, Sung Eun Kim, Yong Soo Kim, Young Min Shin, Sung In Jeong, Sun-Young Jo, Hui-Jeong Gwon, Jong-seok Park, Young-Chang Nho, Jong-Cheol Kim, Seong-Jang Kim, and HeungSoo Shin "Properties of herbal extracts against Propionibacterium acnes for biomedical application", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 854849 (24 October 2012); https://doi.org/10.1117/12.2000074

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