Hybrid organic-inorganic near-infrared responsive magnetic nanoparticles were synthesized for theragnosis combined with localized therapy. In detail, inorganic super-paramagnetic nanoparticles were embedded inside organic polyaniline matrix, which enables localized photothermal therapy upon NIR illumination under intracellular acidic/oxidative condition. In this structure, super-paramagnetic nanoparticle works as MRI contrast agent, that enables the visualization of a tumor and polyaniline works for near-infrared responsive tumor ablation.
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Doyeon Bang ; Taeksu Lee ; Jihye Choi ; Joseph Park ; Byunghoon Kang, et al.
Synthesis of hybrid organic-inorganic near-IR responsive magnetic nanoparticles for cancer theragnosis
", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85484G (October 24, 2012); doi:10.1117/12.2001814; http://dx.doi.org/10.1117/12.2001814