Synthesis of iron oxide nanotubes and their applications in neuroscience and drug delivery

Linfeng Chen; Jining Xie; Kiran R. Aatre; Justin Yancey; Malathi Srivatsan; Vijay K. Varadan

doi:10.1117/12.946051

24 October 2012 Synthesis of iron oxide nanotubes and their applications in neuroscience and drug delivery

Linfeng Chen, Jining Xie, Kiran R. Aatre, Justin Yancey, Malathi Srivatsan, Vijay K. Varadan

Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 854867 (2012) https://doi.org/10.1117/12.946051
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of

Abstract

This paper reports the synthesis of three types of iron oxide nanotubes, including hematite (α-Fe₂O₃), maghemite (γ-Fe₂O₃) and magnetite (Fe₃O₄), and their applications in neuroscience and drug delivery. Two methods, template-assisted thermal decomposition method and hydrothermal method, were used for synthesizing hematite nanotubes, and maghemite nanotubes were obtained from hematite nanotubes by thermal treatment. Template-assisted filtering method was used for synthesizing magnetite nanotubes from ferrofluid. The crystalline, morphology and magnetic properties of the synthesized iron oxide nanotubes were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and vibrating sample magnetometer (VSM), respectively. The biocompatibility of the synthesized hematite nanotubes was confirmed by the survival and differentiation of PC12 cells in the presence of the hematite nanotubes coupled to nerve growth factor (NGF). The capacity of hematite nanotubes for coupling and leasing NGF was confirmed by cultivating PC12 cells in the presence of NGF-loaded hematite nanotubes. The drug loading and release capabilities of hematite nanotubes were tested by using ibuprofen sodium salt (ISS) as a drug model. Based on the experimental results presented in this paper, it can be concluded that iron oxide nanotubes have good biocompatibility with neurons, could be used in guding neurite growth, and are promising candidates for drug delivery.

Citation Download Citation

Linfeng Chen, Jining Xie, Kiran R. Aatre, Justin Yancey, Malathi Srivatsan, and Vijay K. Varadan "Synthesis of iron oxide nanotubes and their applications in neuroscience and drug delivery", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 854867 (24 October 2012); https://doi.org/10.1117/12.946051

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