Larynx cancer is one of the most common primary head and neck cancers. For early-stage laryngeal cancer, both
surgery and radiotherapy are effective treatment modalities, offering a high rate of local control and cure. Optical
coherence tomography (OCT) is an established non-invasive optical biopsy method, capable of imaging ranges of 2-
3 mm into tissue. By using the principles of low coherence light interferometry, OCT can be used to distinguish
normal from unhealthy laryngeal mucosa in patients. Two forward-looking endoscope OCT probes of different sizes
in a sweeping frequency OCT (SS-OCT) configuration were compared in terms of their performances for ex-vivo
laryngeal cancer imaging.
The setup configuration of the first OCT probe unit was designed and constructed at the Institute of Applied Physics
RAS, Russia (diameter of 1.9 mm and the rigid part at the distal end is 13 mm long). The second OCT endoscope
probe was constructed at the Department of Biomedical Engineering at Johns Hopkins University, USA, using a
tubular piezoelectric actuator with quartered electrodes in combination with a resonant fiber cantilever (diameter of
2.4 mm, and rigid part of 45 mm).
Cross-sectional images of laryngeal lesions using the two OCT configurations were aquired and compared with
OCT images obtained in a 1310 nm SS-OCT classical non-endoscopic system. The work presented here is an
intermediate step in our research towards in-vivo endoscopic laryngeal cancer imaging.© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
R. Cernat ; T. Tatla ; J.-Y. Pang ; P. J. Tadrous ; G. Gelikonov, et al.
"<i>Ex-vivo</i> endoscopic laryngeal cancer imaging using two forward-looking fiber optic scanning endoscope probes", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85533A (December 11, 2012); doi:10.1117/12.999905; http://dx.doi.org/10.1117/12.999905