Ex-vivo endoscopic laryngeal cancer imaging using two forward-looking fiber optic scanning endoscope probes

R. Cernat; T. Tatla; J.-Y. Pang; P. J. Tadrous; G. Gelikonov; V. Gelikonov; Y. Y. Zhang; A. Bradu; X. D. Li; A. Gh. Podoleanu

doi:10.1117/12.999905

11 December 2012 Ex-vivo endoscopic laryngeal cancer imaging using two forward-looking fiber optic scanning endoscope probes

R. Cernat, T. Tatla, J.-Y. Pang, P. J. Tadrous, G. Gelikonov, V. Gelikonov, Y. Y. Zhang, A. Bradu, X. D. Li, A. Gh. Podoleanu

Author Affiliations +

Proceedings Volume 8553, Optics in Health Care and Biomedical Optics V; 85533A (2012) https://doi.org/10.1117/12.999905
Event: Photonics Asia, 2012, Beijing, China

Abstract

Larynx cancer is one of the most common primary head and neck cancers. For early-stage laryngeal cancer, both surgery and radiotherapy are effective treatment modalities, offering a high rate of local control and cure. Optical coherence tomography (OCT) is an established non-invasive optical biopsy method, capable of imaging ranges of 2- 3 mm into tissue. By using the principles of low coherence light interferometry, OCT can be used to distinguish normal from unhealthy laryngeal mucosa in patients. Two forward-looking endoscope OCT probes of different sizes in a sweeping frequency OCT (SS-OCT) configuration were compared in terms of their performances for ex-vivo laryngeal cancer imaging. The setup configuration of the first OCT probe unit was designed and constructed at the Institute of Applied Physics RAS, Russia (diameter of 1.9 mm and the rigid part at the distal end is 13 mm long). The second OCT endoscope probe was constructed at the Department of Biomedical Engineering at Johns Hopkins University, USA, using a tubular piezoelectric actuator with quartered electrodes in combination with a resonant fiber cantilever (diameter of 2.4 mm, and rigid part of 45 mm). Cross-sectional images of laryngeal lesions using the two OCT configurations were aquired and compared with OCT images obtained in a 1310 nm SS-OCT classical non-endoscopic system. The work presented here is an intermediate step in our research towards in-vivo endoscopic laryngeal cancer imaging.

Citation Download Citation

R. Cernat, T. Tatla, J.-Y. Pang, P. J. Tadrous, G. Gelikonov, V. Gelikonov, Y. Y. Zhang, A. Bradu, X. D. Li, and A. Gh. Podoleanu "Ex-vivo endoscopic laryngeal cancer imaging using two forward-looking fiber optic scanning endoscope probes", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85533A (11 December 2012); https://doi.org/10.1117/12.999905

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available