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Proceedings Article

Effects of combined xenon and hypothermia on cerebral blood flow and oxygen consumption in newborn piglets measured with a time-resolved near-infrared technique

[+] Author Affiliations
Mohammad Fazel Bakhsheshi, Jennifer Hadway, Laura B. Morrison, Mamadou Diop, Keith St. Lawrence, Ting-Yim Lee

Lawson Health Research Institute (Canada)

Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790S (February 15, 2013); doi:10.1117/12.2004700
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From Conference Volume 8579

  • Optical Interactions with Tissue and Cells XXIV
  • E. Duco Jansen; Robert J. Thomas
  • San Francisco, California, USA | February 02, 2013

abstract

Mild hypothermia (HT), in which the brain is cooled to 32-33°C, has been shown to be neuroprotective for neurological emergencies such as head trauma and neonatal asphyxia. Xenon (Xe), a scarce and expensive anesthetic gas, has also shown great promise as a neuroprotectant, particularly when combined with HT. The purpose of the present study was to investigate the combined effect of Xe and HT on the cerebral metabolic rate of oxygen (CMRO2) and cerebral blood flow (CBF). A closed circuit re-breathing system was used to deliver the Xe in order to make the treatment efficient and economical. A bolus-tracking method using indocyanine green (ICG) as a flow tracer with time-resolved near-infrared (TR-NIR) technique was used to measure CBF and CMRO2 in newborn piglets. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Mohammad Fazel Bakhsheshi ; Jennifer Hadway ; Laura B. Morrison ; Mamadou Diop ; Keith St. Lawrence, et al.
" Effects of combined xenon and hypothermia on cerebral blood flow and oxygen consumption in newborn piglets measured with a time-resolved near-infrared technique ", Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790S (February 15, 2013); doi:10.1117/12.2004700; http://dx.doi.org/10.1117/12.2004700


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