Mild hypothermia (HT), in which the brain is cooled to 32-33°C, has been shown to be neuroprotective for neurological emergencies such as head trauma and neonatal asphyxia. Xenon (Xe), a scarce and expensive anesthetic gas, has also shown great promise as a neuroprotectant, particularly when combined with HT. The purpose of the present study was to investigate the combined effect of Xe and HT on the cerebral metabolic rate of oxygen (CMRO2) and cerebral blood flow (CBF). A closed circuit re-breathing system was used to deliver the Xe in order to make the treatment efficient and economical. A bolus-tracking method using indocyanine green (ICG) as a flow tracer with time-resolved near-infrared (TR-NIR) technique was used to measure CBF and CMRO2 in newborn piglets.
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Mohammad Fazel Bakhsheshi ; Jennifer Hadway ; Laura B. Morrison ; Mamadou Diop ; Keith St. Lawrence, et al.
Effects of combined xenon and hypothermia on cerebral blood flow and oxygen consumption in newborn piglets measured with a time-resolved near-infrared technique
", Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790S (February 15, 2013); doi:10.1117/12.2004700; http://dx.doi.org/10.1117/12.2004700