Effects of combined xenon and hypothermia on cerebral blood flow and oxygen consumption in newborn piglets measured with a time-resolved near-infrared technique

Mohammad Fazel Bakhsheshi; Jennifer Hadway; Laura B. Morrison; Mamadou Diop; Keith St. Lawrence; Ting-Yim Lee

doi:10.1117/12.2004700

15 February 2013 Effects of combined xenon and hypothermia on cerebral blood flow and oxygen consumption in newborn piglets measured with a time-resolved near-infrared technique

Mohammad Fazel Bakhsheshi, Jennifer Hadway, Laura B. Morrison, Mamadou Diop, Keith St. Lawrence, Ting-Yim Lee

Author Affiliations +

Proceedings Volume 8579, Optical Interactions with Tissue and Cells XXIV; 85790S (2013) https://doi.org/10.1117/12.2004700
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Mild hypothermia (HT), in which the brain is cooled to 32-33°C, has been shown to be neuroprotective for neurological emergencies such as head trauma and neonatal asphyxia. Xenon (Xe), a scarce and expensive anesthetic gas, has also shown great promise as a neuroprotectant, particularly when combined with HT. The purpose of the present study was to investigate the combined effect of Xe and HT on the cerebral metabolic rate of oxygen (CMRO₂) and cerebral blood flow (CBF). A closed circuit re-breathing system was used to deliver the Xe in order to make the treatment efficient and economical. A bolus-tracking method using indocyanine green (ICG) as a flow tracer with time-resolved near-infrared (TR-NIR) technique was used to measure CBF and CMRO₂ in newborn piglets.

Citation Download Citation

Mohammad Fazel Bakhsheshi, Jennifer Hadway, Laura B. Morrison, Mamadou Diop, Keith St. Lawrence, and Ting-Yim Lee "Effects of combined xenon and hypothermia on cerebral blood flow and oxygen consumption in newborn piglets measured with a time-resolved near-infrared technique", Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790S (15 February 2013); https://doi.org/10.1117/12.2004700

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