Monolithic silicon interferometric optoelectronic devices for label-free multi-analyte biosensing applications

K. Misiakos; E. Makarona; I. Raptis; A. Salapatas; A. Psarouli; S. Kakabakos; P. Petrou; M. Hoekman; R. Stoffer; K. Tukkiniemi; G. Jobst

doi:10.1117/12.2001791

14 March 2013 Monolithic silicon interferometric optoelectronic devices for label-free multi-analyte biosensing applications

K. Misiakos, E. Makarona, I. Raptis, A. Salapatas, A. Psarouli, S. Kakabakos, P. Petrou, M. Hoekman, R. Stoffer, K. Tukkiniemi, G. Jobst

Author Affiliations +

Proceedings Volume 8629, Silicon Photonics VIII; 862906 (2013) https://doi.org/10.1117/12.2001791
Event: SPIE OPTO, 2013, San Francisco, California, United States

Abstract

Miniaturized bioanalytical devices find wide applications ranging from blood tests to environmental monitoring. Such devices in the form of hand held personal laboratories can transform point-of-care monitoring provided miniaturization, multianalyte detection and sensitivity issues are successfully resolved. Optical detection in biosensors is superior in many respects to other types of sensing based on alternative signal transduction techniques, especially when both sensitivity and label free detection is sought. The main drawback of optical biosensing transducers relates to the unresolved manufacturability issues encountered when attempting monolithic integration of the light source. If the mature silicon processing technology could be used to monolithically integrate optical components, including light emitting devices, into complete photonic sensors, then the lab on a chip concept would materialize into a robust and affordable way. Here, we describe and demonstrate a bioanalytical device consisting of a monolithic silicon optocoupler properly engineered as a planar interferometric microchip. The optical microchip monolithically integrates silicon light emitting diodes and detectors optically coupled through silicon nitride waveguides designed to form Mach-Zehnder interferometers. Label free detection of proteins is demonstrated down to pM sensitivities.

Citation Download Citation

K. Misiakos, E. Makarona, I. Raptis, A. Salapatas, A. Psarouli, S. Kakabakos, P. Petrou, M. Hoekman, R. Stoffer, K. Tukkiniemi, and G. Jobst "Monolithic silicon interferometric optoelectronic devices for label-free multi-analyte biosensing applications", Proc. SPIE 8629, Silicon Photonics VIII, 862906 (14 March 2013); https://doi.org/10.1117/12.2001791

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available