Carbon nanotubes have a great potential in the biomedical applications. To use carbon nanotubes in the
treatment of cancer, we synthesized an immunologically modified single-walled carbon nanotube (SWNT)
using a novel immunomodifier, glycated chitosan (GC), as an effective surfactant for SWNT. This new
composition SWNT-GC was stable due to the strong non-covalent binding between SWNT and GC. The
structure of SWNT-GC is presented in this report. The photothermal effect of SWNT-GC was investigated
under irradiation of a near-infrared laser. SWNT-GC retained the optical properties of SWNT and the
immunological properties of GC. Specifically, the SWNT-GC could selectively absorb a 980-nm light and
induce desirable thermal effects in tissue culture and in animals. It could also induce tumor cell
destruction, controlled by the laser settings and the doses of SWNT and GC. Laser+SWNT-GC treatment
could also induce strong expression of heat shock proteins on the surface of tumor cells. This
immunologically modified carbon nanotube could be used for selective photothermal interactions in noninvasive
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ryan T. Griswold ; Brock Henderson ; Jessica Goddard ; Yongqiang Tan ; Tomas Hode, et al.
Photothermal effects of immunologically modified carbon nanotubes
", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820C (February 21, 2013); doi:10.1117/12.999961; http://dx.doi.org/10.1117/12.999961