Anti-tumor response with immunologically modified carbon nanotubes and phototherapy

Joseph T. Acquaviva III; Feifan Zhou; Ellen Boarman; Wei R. Chen

doi:10.1117/12.999993

21 February 2013 Anti-tumor response with immunologically modified carbon nanotubes and phototherapy

Joseph T. Acquaviva III, Feifan Zhou, Ellen Boarman, Wei R. Chen

Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 85820L (2013) https://doi.org/10.1117/12.999993
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

While successes of different cancer therapies have been achieved in various degrees a systemic immune response is needed to effectively treat late-stage, metastatic cancers, and to establish long-term tumor resistance in the patients. A novel method for combating metastatic cancers has been developed using immunologically modified carbon nanotubes in conjunction with phototherapy. Glycated chitosan (GC) is a potent immunological adjuvant capable of increasing host immune responses, including antigen presentation by activation of dendritic cells (DCs) and causing T cell proliferation. GC is also an effective surfactant for nanomaterials. By combining single-walled carbon nanotubes (SWNTs) and GC, immunologically modified carbon nanotubes (SWNT-GC) were constructed. The SWNT-GC suspension retains the enhanced light absorption properties in the near infrared (NIR) region and the ability to enter cells, which are characteristic of SWNTs. The SWNT-GC also retains the immunological properties of GC. Cellular SWNT-GC treatments increased macrophage activity, DC activation and T cell proliferation. When cellular SWNT-GC was irradiated with a laser of an appropriate wavelength, these immune activities could be enhanced. The combination of laser irradiation and SWNT-GC induced cellular toxicity in targeted tumor cells, leading to a systemic antitumor response. Immunologically modified carbon nanotubes in conjunction with phototherapy is a novel and promising method to produce a systemic immune response for the treatment of metastatic cancers.

Citation Download Citation

Joseph T. Acquaviva III, Feifan Zhou, Ellen Boarman, and Wei R. Chen "Anti-tumor response with immunologically modified carbon nanotubes and phototherapy", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820L (21 February 2013); https://doi.org/10.1117/12.999993

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KEYWORDS

Single walled carbon nanotubes

Tumors

Phototherapy

Carbon nanotubes

Cancer

Therapeutics

Laser therapeutics

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