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Proceedings Article

Anti-tumor response with immunologically modified carbon nanotubes and phototherapy

[+] Author Affiliations
Joseph T. Acquaviva, Ellen Boarman, Wei R. Chen

Univ. of Central Oklahoma (United States)

Feifan Zhou

South China Normal Univ. (China)

Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820L (February 21, 2013); doi:10.1117/12.999993
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From Conference Volume 8582

  • Biophotonics and Immune Responses VIII
  • Wei R. Chen
  • San Francisco, California, USA | February 02, 2013

abstract

While successes of different cancer therapies have been achieved in various degrees a systemic immune response is needed to effectively treat late-stage, metastatic cancers, and to establish long-term tumor resistance in the patients. A novel method for combating metastatic cancers has been developed using immunologically modified carbon nanotubes in conjunction with phototherapy. Glycated chitosan (GC) is a potent immunological adjuvant capable of increasing host immune responses, including antigen presentation by activation of dendritic cells (DCs) and causing T cell proliferation. GC is also an effective surfactant for nanomaterials. By combining single-walled carbon nanotubes (SWNTs) and GC, immunologically modified carbon nanotubes (SWNT-GC) were constructed. The SWNT-GC suspension retains the enhanced light absorption properties in the near infrared (NIR) region and the ability to enter cells, which are characteristic of SWNTs. The SWNT-GC also retains the immunological properties of GC. Cellular SWNT-GC treatments increased macrophage activity, DC activation and T cell proliferation. When cellular SWNT-GC was irradiated with a laser of an appropriate wavelength, these immune activities could be enhanced. The combination of laser irradiation and SWNT-GC induced cellular toxicity in targeted tumor cells, leading to a systemic antitumor response. Immunologically modified carbon nanotubes in conjunction with phototherapy is a novel and promising method to produce a systemic immune response for the treatment of metastatic cancers. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Joseph T. Acquaviva ; Feifan Zhou ; Ellen Boarman and Wei R. Chen
" Anti-tumor response with immunologically modified carbon nanotubes and phototherapy ", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820L (February 21, 2013); doi:10.1117/12.999993; http://dx.doi.org/10.1117/12.999993


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