Assessments of urine cofilin-1 in patients hospitalized in the intensive care units with acute kidney injury

Yi-Jang Lee; Cheng-Han Chao; Ying-Feng Chang; Chien Chou

doi:10.1117/12.2001000

21 February 2013 Assessments of urine cofilin-1 in patients hospitalized in the intensive care units with acute kidney injury

Yi-Jang Lee, Cheng-Han Chao, Ying-Feng Chang, Chien Chou

Author Affiliations +

Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 85820N (2013) https://doi.org/10.1117/12.2001000
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

The actin depolymerizing factor (ADF)/cofilin protein family has been reported to be associated with ischemia induced renal disorders. Here we examine if cofilin-1 is associated with acute kidney injury (AKI). We exploited a 96-well based fiber-optic biosensor that uses conjugated gold nanoparticles and a sandwich immunoassay to detect the urine cofilin-1 level of AKI patients. The mean urine cofilin-1 level of the AKI patients was two-fold higher than that of healthy adults. The receiver operating characteristic (ROC) curve showed that cofilin-1 is a potential biomarker for discriminating AKI patients from healthy adults for intensive care patients.

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Yi-Jang Lee, Cheng-Han Chao, Ying-Feng Chang, and Chien Chou "Assessments of urine cofilin-1 in patients hospitalized in the intensive care units with acute kidney injury", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820N (21 February 2013); https://doi.org/10.1117/12.2001000

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KEYWORDS

Injuries

Kidney

Proteins

Control systems

Ischemia

Cytoskeletons

Biomedical optics

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