Random scattering and aberrations severely limit the imaging depth in optical microscopy. We introduce a rapid, parallel
wavefront compensation technique that efficiently compensates even highly complex phase distortions. Using coherence
gated backscattered light as a feedback signal, we focus light deep inside highly scattering brain tissue. We demonstrate
that the same wavefront optimization technique can also be used to compensate spectral phase distortions in ultrashort
laser pulses using nonlinear iterative feedback. We can restore transform limited pulse durations at any selected target
location and compensate for dispersion that has occurred in the optical train and within the sample.
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Reto Fiolka and Meng Cui
High speed phase distortion measurement and compensation for focusing in space and time
", Proc. SPIE 8589, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XX, 85890V (February 22, 2013); doi:10.1117/12.2001121; http://dx.doi.org/10.1117/12.2001121