Non-compressible hemorrhages are the most common preventable cause of death on battlefield or in civilian traumatic
injuries. We report the use of sub-millisecond pulses of electric current to induce rapid constriction in femoral and
mesenteric arteries and veins in rats. Extent of vascular constriction could be modulated by pulse duration, amplitude
and repetition rate. Electrically-induced vasoconstriction could be maintained at steady level until the end of
stimulation, and blood vessels dilated back to their original size within a few minutes after the end of stimulation. At
higher settings, a blood clotting could be introduced, leading to complete and permanent occlusion of the vessels. The
latter regime dramatically decreased the bleeding rate in the injured femoral and mesenteric arteries, with a complete
hemorrhage arrest achieved within seconds. The average blood loss from the treated femoral artery was about 7 times
less than that of a non-treated control. This new treatment modality offers a promising approach to non-damaging
control of bleeding during surgery, and to efficient hemorrhage arrest in trauma patients.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yossi Mandel ; Richard Manivanh ; Roopa Dalal ; Phil Huie ; Jenny Wang, et al.
Hemorrhage control by microsecond electrical pulses
", Proc. SPIE 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications, 85850I (February 22, 2013); doi:10.1117/12.2002303; http://dx.doi.org/10.1117/12.2002303