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Proceedings Article

Neurostimulation using subnanosecond electric pulses

[+] Author Affiliations
Shu Xiao, Andrei Pakhomov, Fei Guo, Karl H. Schoenbach

Frank Reidy Research Ctr. for Bioelectrics, Old Dominion Univ. (United States)

Swetha Polisetty

Old Dominion Univ. (United States)

Proc. SPIE 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications, 85850M (February 22, 2013); doi:10.1117/12.2003341
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From Conference Volume 8585

  • Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications
  • Gerald J. Wilmink; Bennett L. Ibey
  • San Francisco, California, USA | February 02, 2013

abstract

We have for the first time recorded action potentials in rat hippocampus neurons when they were stimulated by subnanosecond electric pulses. The preliminary results show that applying a series of pulses allowed the accumulation of depolarization before activating the voltage gated channels. The depolarization only occurred when the electric pulses were applied. It is unclear whether the depolarization is caused by the charge accumulation across the membrane or the cation influx due to the membrane permeabilization. We have also conducted an electromagnetic simulation of delivering subnanosecond pulses to tissues using an impulse radiating antenna. The results show that the pulses can be confined in the deep region in the brain but the amplitude is reduced significantly due to the attenuation of the tissues. A partially lossy dielectric lens may be used to reverse the decreasing trend of the electric field. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Shu Xiao ; Andrei Pakhomov ; Fei Guo ; Swetha Polisetty and Karl H. Schoenbach
" Neurostimulation using subnanosecond electric pulses ", Proc. SPIE 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications, 85850M (February 22, 2013); doi:10.1117/12.2003341; http://dx.doi.org/10.1117/12.2003341


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