Probing multi-scale self-similarity of tissue structures using light scattering spectroscopy: prospects in pre-cancer detection

Subhasri Chatterjee; Nandan K. Das; Satish Kumar; Sonali Mohapatra; Asima Pradhan; Prasanta K. Panigrahi; Nirmalya Ghosh

doi:10.1117/12.2016849

26 February 2013 Probing multi-scale self-similarity of tissue structures using light scattering spectroscopy: prospects in pre-cancer detection

Subhasri Chatterjee, Nandan K. Das, Satish Kumar, Sonali Mohapatra, Asima Pradhan, Prasanta K. Panigrahi, Nirmalya Ghosh

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Proceedings Volume 8699, Saratov Fall Meeting 2012: Optical Technologies in Biophysics and Medicine XIV; and Laser Physics and Photonics XIV; 86990D (2013) https://doi.org/10.1117/12.2016849
Event: Saratov Fall Meeting and Workshop on Laser Physics and Photonics 2012, 2012, Saratov, Russian Federation

Abstract

Multi-resolution analysis on the spatial refractive index inhomogeneities in the connective tissue regions of human cervix reveals clear signature of multifractality. We have thus developed an inverse analysis strategy for extraction and quantification of the multifractality of spatial refractive index fluctuations from the recorded light scattering signal. The method is based on Fourier domain pre-processing of light scattering data using Born approximation, and its subsequent analysis through Multifractal Detrended Fluctuation Analysis model. The method has been validated on several mono- and multi-fractal scattering objects whose self-similar properties are user controlled and known a-priori. Following successful validation, this approach has initially been explored for differentiating between different grades of precancerous human cervical tissues.

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Subhasri Chatterjee, Nandan K. Das, Satish Kumar, Sonali Mohapatra, Asima Pradhan, Prasanta K. Panigrahi, and Nirmalya Ghosh "Probing multi-scale self-similarity of tissue structures using light scattering spectroscopy: prospects in pre-cancer detection", Proc. SPIE 8699, Saratov Fall Meeting 2012: Optical Technologies in Biophysics and Medicine XIV; and Laser Physics and Photonics XIV, 86990D (26 February 2013); https://doi.org/10.1117/12.2016849

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KEYWORDS

Light scattering

Scattering

Refractive index

Tissues

Fractal analysis

Tissue optics

Connective tissue

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