Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

Targeting of systemically-delivered magnetic nanoparticle hyperthermia using a noninvasive, static, external magnetic field

[+] Author Affiliations
Grayson D. Zulauf, B. Stuart Trembly, Brian R. Flint

Thayer School of Engineering at Dartmouth (United States)

Andrew J. Giustini, Rendall R. Strawbridge, P. Jack Hoopes

Geisel School of Medicine (United States)

Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840C (February 26, 2013); doi:10.1117/12.2008816
Text Size: A A A
From Conference Volume 8584

  • Energy-based Treatment of Tissue and Assessment VII
  • Thomas P. Ryan
  • San Francisco, California, USA | February 02, 2013

abstract

One of the greatest challenges of nanoparticle cancer therapy is the delivery of adequate numbers of nanoparticles to the tumor site. Iron oxide nanoparticles (IONPs) have many favorable qualities, including their nontoxic composition, the wide range of diameters in which they can be produced, the cell-specific cytotoxic heating that results from their absorption of energy from a nontoxic, external alternating magnetic field (AMF), and the wide variety of functional coatings that can be applied. Although IONPs can be delivered via an intra-tumoral injection to some tumors, the resulting tumor IONP distribution is generally inadequate; additionally, local tumor injections do not allow for the treatment of systemic or multifocal disease. Consequently, the ultimate success of nanoparticle based cancer therapy likely rests with successful systemic, tumor-targeted IONP delivery. In this study, we used a surface-based, bilateral, noninvasive static magnetic field gradient produced by neodymiumboron- iron magnets (80 T/m to 130 T/m in central plane between magnets), a rabbit ear model, and systemicallydelivered starch-coated 100 nm magnetic (iron oxide) nanoparticles to demonstrate a spatially-defined increase in the local tissue accumulation of IONPs. In this non-tumor model, the IONPs remained within the local vascular space. It is anticipated that this technique can be used to enhance IONP delivery significantly to the tumor parenchyma/cells. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Grayson D. Zulauf ; B. Stuart Trembly ; Andrew J. Giustini ; Brian R. Flint ; Rendall R. Strawbridge, et al.
" Targeting of systemically-delivered magnetic nanoparticle hyperthermia using a noninvasive, static, external magnetic field ", Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840C (February 26, 2013); doi:10.1117/12.2008816; http://dx.doi.org/10.1117/12.2008816


Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.