The use of magnetic nanoparticles (mNP’s) to induce local hyperthermia has been emerging in recent years as a
promising cancer therapy, in both a stand-alone and combination treatment setting. Studies have shown that cancer cells
associate with, internalize, and aggregate mNP’s more preferentially than normal cells. Once the mNP’s are delivered
inside the cells, a low frequency (30 kHz-300 kHz) alternating electromagnetic field is used to activate the mNP’s. The
nanoparticles absorb the applied field and provide localized heat generation at nano-micron scales. It has been shown
experimentally that mNP’s exhibit collective behavior when in close proximity. Although most prevailing mNP heating
models assume there is no magnetic interaction between particles, our data suggests that magnetic interaction effects due
to mNP aggregation are often significant; In the case of multi-crystal core particles, interaction is guaranteed. To
understand the physical phenomena responsible for this effect, we modeled electromagnetic coupling between mNP’s in
detail. The computational results are validated using data from the literature as well as measurements obtained in our
lab. The computational model presented here is based on a method of moments technique and is used to calculate
magnetic field distributions on the nanometer scale, both inside and outside the mNP.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Robert V. Stigliano ; Fridon Shubitidze ; Katsiaryna Kekalo ; Ian Baker ; Andrew J. Giustini, et al.
Understanding mNP hyperthermia for cancer treatment at the cellular scale
", Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840E (February 26, 2013); doi:10.1117/12.2007518; http://dx.doi.org/10.1117/12.2007518