0

Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

Iron oxide nanoparticle enhancement of radiation cytotoxicity

[+] Author Affiliations
Courtney M. Mazur

Brown Univ. (United States)

Jennifer A. Tate, Rendall R. Strawbridge, David J. Gladstone, P. Jack Hoopes

Thayer School of Engineering at Dartmouth (United States)

Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840J (February 26, 2013); doi:10.1117/12.2007701
Text Size: A A A
From Conference Volume 8584

  • Energy-based Treatment of Tissue and Assessment VII
  • Thomas P. Ryan
  • San Francisco, California, USA | February 02, 2013

abstract

Iron oxide nanoparticles (IONPs) have been investigated as a promising means for inducing tumor cell-specific hyperthermia. Although the ability to generate and use nanoparticles that are biocompatible, tumor specific, and have the ability to produce adequate cytotoxic heat is very promising, significant preclinical and clinical development will be required for clinical efficacy. At this time it appears using IONP-induced hyperthermia as an adjunct to conventional cancer therapeutics, rather than as an independent treatment, will provide the initial IONP clinical treatment. Due to their high-Z characteristics, another option is to use intracellular IONPs to enhance radiation therapy without excitation with AMF (production of heat). To test this concept IONPs were added to cell culture media at a concentration of 0.2 mg Fe/mL and incubated with murine breast adenocarcinoma (MTG-B) cells for either 48 or 72 hours. Extracellular iron was then removed and all cells were irradiated at 4 Gy. Although samples incubated with IONPs for 48 hrs did not demonstrate enhanced post-irradiation cytotoxicity as compared to the non-IONP-containing cells, cells incubated with IONPs for 72 hours, which contained 40% more Fe than 48 hr incubated cells, showed a 25% decrease in clonogenic survival compared to their non-IONP-containing counterparts. These results suggest that a critical concentration of intracellular IONPs is necessary for enhancing radiation cytotoxicity. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Courtney M. Mazur ; Jennifer A. Tate ; Rendall R. Strawbridge ; David J. Gladstone and P. Jack Hoopes
" Iron oxide nanoparticle enhancement of radiation cytotoxicity ", Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840J (February 26, 2013); doi:10.1117/12.2007701; http://dx.doi.org/10.1117/12.2007701


Access This Article
Sign In to Access Full Content
Please Wait... Processing your request... Please Wait.
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
 

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement

Buy this article ($18 for members, $25 for non-members).
Sign In