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Proceedings Article

Computational analysis of optical coherence tomography images for the detection of soft tissue sarcomas

[+] Author Affiliations
Shang Wang, Narendran Sudheendran, Chih-Hao Liu, Ravi K. Manapuram, Kirill V. Larin

Univ. of Houston (United States)

Valery P. Zakharov

Samara State Aerospace Univ. (Russian Federation)

Davis R. Ingram, Alexander J. Lazar, Dina C. Lev, Raphael E. Pollock

The Univ. of Texas MD Anderson Cancer Ctr. (United States)

Proc. SPIE 8580, Dynamics and Fluctuations in Biomedical Photonics X, 85800T (February 28, 2013); doi:10.1117/12.2006638
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From Conference Volume 8580

  • Dynamics and Fluctuations in Biomedical Photonics X
  • Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang
  • San Francisco, California, USA | February 02, 2013

abstract

We present a computational method for the analysis of optical coherence tomography (OCT) images to detect soft tissue sarcomas. The method combines the quantitative analysis of two aspects of information from the intensity A-lines of OCT images; one is the slope of the intensity A-line with dB unit, which is determined by the optical attenuation characteristics of tissue; the other is the standard deviation (SD) of the slope-removed intensity A-line, which is dependent on the tissue structural features. The method is tested with pilot experiments on ex vivo tissue samples of human fat, muscle, well differentiated liposarcoma (WDLS) and leiomyosarcoma. Our results demonstrate the feasibility of this quantitative method in the differentiation of soft tissue sarcomas from normal tissues. This study indicates that OCT can be a potential computer-aided means of automatically and accurately identifying resection margins of soft tissues sarcomas during surgical treatment. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Shang Wang ; Narendran Sudheendran ; Chih-Hao Liu ; Ravi K. Manapuram ; Valery P. Zakharov, et al.
" Computational analysis of optical coherence tomography images for the detection of soft tissue sarcomas ", Proc. SPIE 8580, Dynamics and Fluctuations in Biomedical Photonics X, 85800T (February 28, 2013); doi:10.1117/12.2006638; http://dx.doi.org/10.1117/12.2006638


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