Photoacoustic microscopy with 7.6-µm axial resolution

Chi Zhang; Konstantin Maslov; Junjie Yao; Lihong V. Wang

doi:10.1117/12.2003248

4 March 2013 Photoacoustic microscopy with 7.6-μm axial resolution

Chi Zhang, Konstantin Maslov, Junjie Yao, Lihong V. Wang

Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 85812W (2013) https://doi.org/10.1117/12.2003248
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

The axial resolution of photoacoustic microscopy (PAM) is much lower than its lateral resolution, which resolves down to the submicron level. Here we achieved so far the highest axial resolution of 7.6 μm by using a commercial 125 MHz ultrasonic transducer for signal detection, followed by the Wiener deconvolution for signal processing. The axial resolution was validated by imaging two layers of red ink in a wedge shape. Melanoma cells were imaged ex vivo with high axial resolution. Compared with a PAM system with a 50 MHz ultrasonic transducer, our high-axial-resolution PAM system resolved the blood vessels in mouse ears in vivo much more clearly in the depth direction.

Citation Download Citation

Chi Zhang, Konstantin Maslov, Junjie Yao, and Lihong V. Wang "Photoacoustic microscopy with 7.6-μm axial resolution", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85812W (4 March 2013); https://doi.org/10.1117/12.2003248

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KEYWORDS

Ultrasonics

Transducers

Deconvolution

Photoacoustic microscopy

Ear

Image resolution

In vivo imaging

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